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Brain on Fire is a biographical drama based on Susannah Cahalan's memoir, about a young New York Post reporter who rapidly descends into psychosis, experiencing hallucinations, violence, and catatonia, as doctors initially misdiagnose her with psychiatric issues, only for a specialist to discover she has a rare autoimmune disease, Anti-NMDA Receptor Encephalitis, which causes her brain to become inflamed, leading to a desperate medical mystery to save her life